Key result
Higher serum CGRP levels linked to ~12% lower CVD risk in hypertensive men.
Why the study?
Do calcitonin gene-related peptide (CGRP) levels associate with cardiovascular risk markers in newly diagnosed hypertensive male patients?
Case-Control (n=99)
No
Do calcitonin gene-related peptide (CGRP) levels associate with cardiovascular risk markers in newly diagnosed hypertensive male patients?
Odds Ratio: 0.877 (95% CI 0.809–0.951)
p-value: p=0.001
Reduced CGRP levels are significantly associated with higher cardiovascular risk markers, specifically lipid accumulation product, in newly diagnosed hypertensive men.
No takes yet. Share an insight, caveat, or question.
Higher CGRP levels may aid risk stratification in hypertensive men; leaves open causal role and need for prospective validation.
Makkia et al. (2026) conducted a case-control in Hypertension (n=99). Serum CGRP levels vs. Lower CGRP levels was evaluated on Cardiovascular disease risk (multivariable logistic regression) (OR 0.877, 95% CI 0.809-0.951, p=0.001). Higher serum CGRP levels were significantly associated with a reduced risk of cardiovascular disease in hypertensive men (OR 0.877).
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