Key result
Low serum CGRP is linked to ~6-fold higher odds of severe coronary stenosis.
Why the study?
The relationship between serum calcitonin gene-related peptide levels and the severity of coronary stenosis in patients without acute myocardial injury was unclear.
Is a low serum calcitonin gene-related peptide (CGRP) level associated with increased severity of coronary stenosis and MACE in patients undergoing coronary angiography?
Observational (n=233)
Is a low serum calcitonin gene-related peptide (CGRP) level associated with increased severity of coronary stenosis and MACE in patients undergoing coronary angiography?
Odds Ratio: 5.819 (95% CI 2.24–15.116)
p-value: p=<0.001
Low serum CGRP levels are independently associated with more severe angiographic coronary stenosis and a higher risk of 2-year major adverse cardiovascular events.
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May refine pre-angiography risk stratification; leaves open CGRP as therapeutic target pending prospective validation.
Dong et al. (2021) conducted an observational in Coronary heart disease (n=233). Low serum calcitonin gene-related peptide (CGRP) level (<25.05 pg/ml) vs. Higher CGRP level (≥25.05 pg/ml) was evaluated on Severe coronary stenosis (SYNTAX score >22) (OR 5.819, 95% CI 2.240-15.116, p=<0.001). A low serum CGRP level (<25.05 pg/ml) was an independent predictor of severe coronary stenosis (SYNTAX score >22) (OR 5.819; 95% CI 2.240-15.116; P<0.001) and higher 2-year MACE.
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