Key result
Diabetes mellitus and coronary artery disease were associated with significantly decreased serum levels of CGRP and SP compared to controls, with the lowest levels in patients having both conditions.
Why the study?
Are serum levels of calcitonin gene-related peptide and substance P decreased in patients with diabetes mellitus and coronary artery disease?
Observational (n=184)
Are serum levels of calcitonin gene-related peptide and substance P decreased in patients with diabetes mellitus and coronary artery disease?
Serum levels of CGRP and SP are decreased in patients with diabetes and coronary artery disease, suggesting these neuropeptides may play a role in CAD pathogenesis in diabetic patients.
No takes yet. Share an insight, caveat, or question.
Decreased CGRP/SP levels may inform diabetic CAD mechanisms; hypothesis-generating and should not change practice pending prospective studies.
Wang et al. (2012) conducted an observational in Diabetes Mellitus and Coronary Artery Disease (n=184). Diabetes mellitus and coronary artery disease vs. Patients without diabetes mellitus or coronary artery disease was evaluated on Serum levels of calcitonin gene-related peptide (CGRP) and substance P (SP). Diabetes mellitus and coronary artery disease were associated with significantly decreased serum levels of CGRP and SP compared to controls, with the lowest levels in patients having both conditions.
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