What question did this study set out to answer?

The study aims to elucidate how CD27 enhances Jun N-terminal kinase signaling in T lymphocytes.

March 2, 2026Journal of Marine Fisheries

The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2

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Research shows CD27 signals to Jun N-terminal kinase in lymphocytes, suggesting roles in T cell survival and proliferation.

The study aims to elucidate how CD27 enhances Jun N-terminal kinase signaling in T lymphocytes.
Conducted a yeast two-hybrid screen to identify interactions with CD27.
Used dominant negative Traf-2 in transfection experiments to assess signaling dynamics.
Examined primary murine lymph node T cells for JNK activity enhancement.
CD27 was found to enhance TCR-induced JNK activity in T cells.
CD27 directly associates with Traf-2, facilitating JNK signaling.
Suggests CD27 has roles in both T cell proliferation and survival.

Gravestein et al. (1998) studied this question.

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