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This research examines how CD27 influences T cell activation and two distinct subsets of CD4 T cells.

CD27, a member of the nerve growth factor receptor family, is preferentially expressed on CD45RA+ CD4 T cell clones and involved in distinct immunoregulatory functions

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This research examines how CD27 influences T cell activation and two distinct subsets of CD4 T cells.
Developed T cell clones from isolated CD4+CD45RA+ and CD4+CD45RO+ populations using PHA stimulation.
Assessed CD27 expression and activation in CD4 T cell subsets over time.
Performed functional assays to evaluate cytokine production and immunoregulatory activity.
CD27 is preferentially expressed on CD45RA+ T cells, maintained post-activation, while low in CD45RA- T cells.
Four out of six CD45RA+ T cell clones demonstrated suppressor activity in IgG synthesis.
Blocking CD27 with anti-CD27 mAb elevated intracellular cAMP levels, indicating a role in suppressor function.

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Randomized trial analyzes CD27's role in T cell activation and immunoregulation in T cell subsets, suggesting important implications.

Sugita et al. (1992) studied this question.

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