In two porcine myocardial infarction models followed for 11 weeks, infarct size measured by LGE decreased from 35.8% to 20.3% and 26.0% to 14.4%, native T1 increased over time, infarct wall thickness decreased (slopes −0.5 and −1.2 mm/week), EDV and ESV increased, EF decreased (slopes −0.9% and −2.4% per week), regional intracardiac vorticity remained preserved, while the helical filling vortex angle increased progressively (slopes 0.6° and 0.8° per week).
In a porcine model of myocardial infarction, the angle of the helical filling vortex shows potential as a novel imaging marker for left ventricular remodeling.
In this exploratory longitudinal study, both animals demonstrated similar temporal patterns of LV remodeling after MI, despite differences in the absolute magnitude of the measured parameters. In addition, our findings suggest that the angle of the helical filling vortex may have potential as a remodeling marker, which warrants validation in larger cohorts.
Park et al. (Fri,) conducted a other in Porcine models with experimentally induced myocardial infarction at the left anterior descending artery (n=2). Coronary artery balloon catheter occlusion of mid left anterior descending artery to induce myocardial infarction vs. Baseline (pre-infarction) measurements was evaluated on Left ventricular remodeling and intracardiac flow characteristics assessed by cardiac MRI (LGE, native T1/T2 mapping, ECV), global LV function (EDV, ESV, EF), strain, and 4D flow MRI parameters including vorticity and vortex angle. In two porcine myocardial infarction models followed for 11 weeks, infarct size measured by LGE decreased from 35.8% to 20.3% and 26.0% to 14.4%, native T1 increased over time, infarct wall thickness decreased (slopes −0.5 and −1.2 mm/week), EDV and ESV increased, EF decreased (slopes −0.9% and −2.4% per week), regional intracardiac vorticity remained preserved, while the helical filling vortex angle increased progressively (slopes 0.6° and 0.8° per week).