March 4, 2026Diabetes

Unraveling Diabetic Cardiomyopathy (DCM): The Critical Role of the Yap–miR-22-3p–Sirt1 Axis in the Pathogenesis of DCM

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Key result

High glucose promotes diabetic cardiomyopathy in T2D models by activating the Yap-miR-22-3p-Sirt1 axis.

Why the study?

Yes-associated protein (Yap) modulates cardiac remodeling and function in various cardiovascular diseases, but its role in diabetic cardiomyopathy was unclear.

Population

Mice with type 2 diabetes mellitus

Design

Animal and cellular experimental study

Authors

YLYilang LiHainan University YZYuan ZengNanchang Institute of Technology YLYuling LianState Key Laboratory of Respiratory Disease

Discussion

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Implication

Should not yet change practice in diabetic cardiomyopathy; extends evidence for Yap–miR-22-3p–Sirt1 axis as novel therapeutic target.

Key Points

This research aims to clarify the role of the Yap–miR-22-3p–Sirt1 axis in the pathogenesis of diabetic cardiomyopathy.
Investigated Yap activity in mouse models of type 2 diabetes mellitus
Examined the effects of high glucose and palmitic acid on Yap, miR-22-3p, and Sirt1
Analyzed molecular pathways linked to myocardial structure and function
High glucose and palmitic acid increased Yap activity
Yap activation promoted miR-22-3p expression while inhibiting Sirt1 expression
The Yap-miR-22-3p-Sirt1 axis is crucial in the development of diabetic cardiomyopathy

Structured PICO

Population

Mice with type 2 diabetes mellitus and in vitro models

Intervention

Exposure to high glucose or high glucose plus palmitic acid levels

Outcome

Myocardial structure and function, and molecular expression (Yap activity, miR-22-3p, and Sirt1 expression)surrogate

The Yap-miR-22-3p-Sirt1 axis plays a critical role in the pathogenesis of diabetic cardiomyopathy, offering a potential novel therapeutic target.

Cite This Study

Li et al. (2026) studied this question. High glucose activates the Yap–miR-22-3p–Sirt1 axis, promoting diabetic cardiomyopathy by impairing myocardial structure and function in type 2 diabetes models.

synapsesocial.com/papers/69a7cd2ad48f933b5eed9410 https://doi.org/10.2337/db25-0435

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Unraveling Diabetic Cardiomyopathy (DCM): The Critical Role of the Yap–miR-22-3p–Sirt1 Axis in the Pathogenesis of DCM

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Unraveling Diabetic Cardiomyopathy (DCM): The Critical Role of the Yap–miR-22-3p–Sirt1 Axis in the Pathogenesis of DCM

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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