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March 5, 2026

Electrospun Silk Fibroin/Poly(Vinyl Alcohol) Nanofibrous Dressings Co-Loaded With Teicoplanin and Liposomal Curcumin: Fabrication, Physicochemical Characterization, and Antibacterial Performance.

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Authors

FEFariba Alizadeh EghtedarJMJebrail MovaffaghAMAmir Mahdi Molavi

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Overview

Fabrication of nanofibrous dressings with teicoplanin and curcumin demonstrates enhanced antibacterial properties, indicating potential for improved wound healing.

Key Points

  • The study aims to develop nanofibrous dressings that integrate antibacterial agents to enhance wound healing.
  • Fabricated electrospun dressings using silk fibroin and poly(vinyl alcohol)
  • Co-loaded with teicoplanin and liposomal curcumin
  • Conducted physicochemical characterization, including tensile testing and drug-release assays
  • Evaluated antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa
  • Assessed cytocompatibility and hemocompatibility
  • Produced defect-free nanofibers with a diameter confirming ECM mimetic architecture
  • Achieved high water uptake of 364.17% and significant degradation of 45.74% after 28 days
  • Demonstrated a breaking strength of 5.39 MPa appropriate for wound applications
  • Showed robust drug release profiles: 666.31 ± 6.85 μg/mL teicoplanin in first 24 hours and steady curcumin release
  • Exhibited synergistic antibacterial effects, surpassing efficacy of single-agent treatments

Cite This Study

Eghtedar et al. (2026) studied this question.

synapsesocial.com/papers/69a91db5d6127c7a504c0cb1https://doi.org/10.1002/jbma.70040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nanofibrous Dressings Modified with Antibacterial Polylysine and Anti-inflammatory Tannic Acid for Infected Wound Healing2025 · 11 citations
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  4. 4Synergistic Tetracycline–Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings2024 · 5 citations
  5. 5Introducing PCL-Based Electrospun Nanocomposite Wound Dressings: Synergistic Effects of Curcumin and Reduced Graphene Oxide2024 · 5 citations