Real-world evidence shows furosemide use improves organ outcomes and coagulopathy in sepsis, suggesting new therapeutic avenues.
Real-world evidence suggests that furosemide use is associated with reduced sepsis-related coagulopathy and favorable organ outcomes. These findings generate a biologically plausible hypothesis consistent with Na +-K +-2Cl - cotransporter 1 (NKCC1)-related antioxidant and anti-inflammatory pathways observed in preclinical models, warranting confirmation in prospective trials.
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Hung et al. (2026) studied this question.
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