Does monitoring eGFR slopes rather than relying solely on specific cut-off values allow early detection of at-risk patients for HF hospitalization or death in HFrEF?
Monitoring eGFR slopes rather than static cut-offs in HFrEF patients may enable early detection of impending heart failure hospitalization or death up to a year in advance.
In HFrEF, kidney function decline may precede a HF hospitalization or death by up to 1 year, linking to symptomatic congestion. Monitoring eGFR slopes rather than relying solely on specific cut-off values may allow early detection of at-risk patients.
Kobayashi et al. (2025) studied this question.