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March 6, 2026ALPHA PSYCHIATRYOpen Access

ERP Decoding Analysis of Visual Working Memory Processes in Schizophrenia

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Authors

ZWZhongsi WangQufu Normal UniversityCLChunlei LiuQufu Normal UniversityYJYuyan JingQufu Normal University

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Implication

Analyzes visual working memory deficits in schizophrenia, indicating potential neural intervention targets.

Key Points

  • The study aims to investigate the neural mechanisms underlying visual working memory deficits in schizophrenia.
  • 46 participants were assessed, including 22 with schizophrenia and 24 healthy controls.
  • A change detection task with varying conditions was employed to evaluate vWM performance.
  • Event-related potential (ERP) analysis focused on contralateral delay activity (CDA) as a key measure.
  • Multivariate pattern classification and searchlight analysis were used to assess neural signaling differences.
  • CDA amplitude was significantly reduced in the schizophrenia group, especially in the condition with two targets and two distractors.
  • Decoding accuracy during the delay period was significantly lower in the schizophrenia group compared to controls.
  • The left parietal region showed the most significant decrease in decoding accuracy in the schizophrenia group.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69aa7096531e4c4a9ff5a8b6https://doi.org/10.31083/ap42597
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