Origins of Spatial Working Memory Deficits in Schizophrenia: An Event-Related fMRI and Near-Infrared Spectroscopy Study
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Why the study?
Does spatial working memory maintenance elicit different prefrontal activation patterns in schizophrenic patients compared to healthy controls?
Population
Schizophrenic patients and healthy control participants
Comparison
Spatial working memory task evaluated with… vs Healthy control participants performing the same…
Design
Case-control
Authors
Discussion
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Implication
Patients may recruit compensatory bilateral networks in schizophrenia; hypothesis-generating for cognitive interventions and leaves open clinical translation.
Structured PICO
Does spatial working memory maintenance elicit different prefrontal activation patterns in schizophrenic patients compared to healthy controls?
P
Population
Schizophrenic patients and healthy control participants
I
Intervention
Spatial working memory task evaluated with event-related functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS)
C
Comparator
Healthy control participants performing the same task
O
Outcome
Brain activation (BOLD signal for fMRI, oxygenated/deoxygenated hemoglobin for NIRS) during the working memory maintenance phasesurrogate
Schizophrenic patients recruit a wider, bilateral network during spatial working memory maintenance compared to the right-lateralized network in healthy controls, even when performance is matched.
Limitations
- Age and education were not matched across groups
- Small sample size
Cite This Study
Lee et al. (2008) studied this question.
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