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June 20, 2026Open Access

The Role of Thalamic Connectivity in Working Memory Impairment in Schizophrenia: Merging Evidence From Fmri and Eeg

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Authors

LSLuz Maria Alliende Serra

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Overview

Randomized trial examines working memory deficits in schizophrenia, revealing neural connectivity differences among groups.

Key Points

  • This study explores the neural correlates underlying visual working memory impairments in schizophrenia.
  • Used non-simultaneous EEG and fMRI recordings from 5 people with schizophrenia (PSZ) and 8 healthy controls (HCS).
  • Participants performed a visual working memory change-detection task under varying memory load conditions.
  • Examined thalamic connectivity's mediating role on signal modulation by load during tasks.
  • PSZ showed less event related desynchronization in the alpha frequency band and less BOLD activation in the PPC and MOG, but these differences were not significant.
  • Load-dependent modulation of event related desynchronization was negatively related to BOLD activation for both PSZ and HCS groups.
  • Higher task connectivity was observed in PSZ between the posterior thalamus and PPC and MOG compared to HCS, who exhibited higher resting-state connectivity.

Cite This Study

Luz Maria Alliende Serra (2021) studied this question.

synapsesocial.com/papers/6a363147db0793dc1a5382e0https://doi.org/10.6082/2w5kx-cka86
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ERP Decoding Analysis of Visual Working Memory Processes in Schizophrenia2026
  2. 2Origins of Spatial Working Memory Deficits in Schizophrenia: An Event-Related fMRI and Near-Infrared Spectroscopy Study2008 · 108 citations
  3. 3Task‐based default mode network connectivity predicts cognitive impairment and negative symptoms in first‐episode schizophrenia2024 · 3 citations
  4. 4Working Memory Dysfunction: An fMRI Analysis in Schizophrenia2025
  5. 5Simultaneous EEG-fMRI Investigation of Rhythm-Dependent Thalamo-Cortical Circuits Alteration in Schizophrenia2024 · 5 citations