Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 6, 2026AMB ExpressOpen Access

Bacillus mojavensis postbiotics: transcriptomic and anticancer effects in colon cancer cells

View Full Paper
Ask AI
Bookmark
Share

Authors

MTMaría Alejandra Trujillo-LópezUniversidad Popular Autónoma del Estado de PueblaCMCristina Muñoz-OlivosUniversidad Popular Autónoma del Estado de PueblaMGMiguel Ángel Garduño-VargasUniversidad Popular Autónoma del Estado de Puebla

Discussion

Loading...

Member takes

Implication

In vitro evaluation reveals postbiotics reduce viability and migration of colon cancer cells, suggesting therapeutic potential.

Key Points

  • The study aims to investigate the anticancer effects of postbiotics derived from Bacillus mojavensis on colon cancer cells.
  • Evaluated antiproliferative activity using MTT and crystal violet assays on SW480 colon cancer cells.
  • Assessed antimigratory effects with a wound-healing assay.
  • Investigated the effects of postbiotics on LPS-induced proliferation in SW480 cells.
  • Tested biosafety using peripheral blood mononuclear cells (PBMCs) from healthy donors.
  • Conducted transcriptomic profiling to identify changes in oncogenes and tumor suppressor pathways.
  • Postbiotic treatment reduced SW480 cell viability by up to 79.3%.
  • Significantly inhibited cell migration after 24 hours.
  • Decreased LPS-induced proliferation without cytotoxic effects on PBMCs.
  • Modulated cancer-related pathways, including PI3K–Akt and MAPK, revealed through transcriptomic profiling.

Cite This Study

Trujillo-López et al. (2026) studied this question.

synapsesocial.com/papers/69aa70f8531e4c4a9ff5b44ehttps://doi.org/10.1186/s13568-026-02018-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bacillus mojavensis postbiotics: transcriptomic and anticancer effects in colon cancer cells2025
  2. 2Evaluation of Postbiotics from Lactiplantibacillus plantarum and Bacillus mojavensis Fermented in Aguamiel on Their Cytotoxic Effect in Breast Cancer Cells, Their In Vivo Effects, and Processing by Spray Drying2026
  3. 3Investigating the therapeutic potential of Bifidobacterium breve and Lactobacillus rhamnosus postbiotics through apoptosis induction in colorectal HT-29 cancer cells2024 · 11 citations
  4. 4Abstract 312: Postbiotic based on sequential fermentation of <i>L.paracasei</i> NPB01 and <i>L.rhamnosus</i> GG exerts antitumor activities against breast cancer.2026
  5. 5Abstract PS2-12-02: An Innovative Postbiotic Product Based on Sequential Fermentation of L.paracasei NPB01 and L.rhamnosus GG Demonstrates Antitumor Activity against Breast Cancer2026