Key result
Bufo marinus angiotensin II receptors show equal arterial and venous numbers but greater arterial flow reduction.
Why the study?
The renin-angiotensin system in amphibians is believed to have arterial and tubular functions, which would be supported by the presence of angiotensin II receptors in both arterial and portal systems of Bufo marinus.
This preclinical study demonstrates the presence of equivalent angiotensin II receptors in the arterial and venous systems of Bufo marinus, supporting dual arterial and tubular functions of the amphibian renin-angiotensin system.
It is believed that the Renin-angiotensin system in amphibians may have both arterial and tubular functions. The presence of angiotensin II receptors in the arterial and portal systems of the Bufo marinus would support this hypothesis. A receptor washout technique was used, involving the perfusion of angiotensin II- ¹²⁵I through both systems, Perfusate flow rates dropped in both systems, with a greater reduction in the arterial side. It was found that an equivalent number of receptors exist in the arterial and venous systems. Speculations were made as to the functions of these receptors.
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Colin Alexander Macpherson (1980) studied this question. Angiotensin II receptors are present in equivalent numbers in both arterial and venous systems of Bufo marinus, with greater perfusate flow reduction in arteries.
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