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To assess whether vaccination strategies are driving genetic changes in African swine fever virus strains in Vietnamese swine.

March 8, 2026

Subtle Genetic Shifts of African Swine Fever Virus Among Vietnamese Domestic Swine Following Live-Attenuated Vaccine Commercialization.

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To assess whether vaccination strategies are driving genetic changes in African swine fever virus strains in Vietnamese swine.
Conducted molecular surveillance of ASFV core genes in non-vaccinated pigs across Central and Southern Vietnam.
Compared ASFV strains before and after the introduction of live-attenuated vaccines.
Analyzed the presence of genetic variations including microvariants and SNPs.
Confirmed spillover and ongoing field circulation of vaccine-related ASFV strains.
Revealed a marked increase in genetic diversity post-vaccine commercialization.
Identified significant changes in ASFV genes impacting viral function and host interactions.

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Molecular surveillance identifies genetic diversity and α-helix changes in African swine fever virus, indicating biosecurity needs.

Nguyen et al. (2026) studied this question.

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