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June 13, 2026BiologyOpen Access

Live-Attenuated Vaccines Against African Swine Fever: Strategies, Lessons, and Prospects

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Authors

CJChunhao JiangRHRuojia HuangRLRui Luo

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Overview

Review summarizes strategies and molecular mechanisms for developing live-attenuated vaccines against African swine fever, indicating promising future solutions.

Key Points

  • This review aims to summarize strategies and analyze molecular challenges in developing live-attenuated vaccines for African swine fever.
  • Systematic review of current strategies for developing live-attenuated vaccines (LAVs) for ASF.
  • Analysis of bottlenecks including intergenotypic ASFV recombination and strain reversion to virulence.
  • Discussion on rational design strategies for next-generation LAVs using advanced technologies.
  • Identified three conventional strategies for developing ASF LAVs.
  • Dissected core molecular bottlenecks that limit ASF control efforts.
  • Proposed rational design strategies that can potentially enhance the efficacy of future ASF vaccines.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056ae0https://doi.org/10.3390/biology15120902
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