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June 20, 2024VaccineOpen Access

Thoughts on the research of African swine fever live-attenuated vaccines

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Why the study?

African swine fever causes substantial economic losses, but no effective commercial vaccine is currently available due to the virus's large genome, numerous encoded proteins, and complex particle structure.

Design

Review

Authors

XCXuefei ChuChina Animal Health and Epidemiology CenterSGShengqiang GeChina Animal Health and Epidemiology CenterYZYuanyuan ZuoChina Animal Health and Epidemiology Center

Discussion

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Member takes

Overview

ASF vaccine progress remains limited by viral complexity; leaves open the feasibility of a safe, effective commercial product.

Structured PICO

P
Population
Pigs (African swine fever virus infection)
I
Intervention
African swine fever live-attenuated vaccines

This review highlights the challenges and strategies in developing a safe and efficient commercial live-attenuated vaccine against African swine fever.

Cite This Study

Chu et al. (2024) studied this question.

synapsesocial.com/papers/6a72395df44fa9f079dfc783https://doi.org/10.1016/j.vaccine.2024.06.020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuated African swine fever viruses and the live vaccine candidates: a comprehensive review2024 · 27 citations
  2. 2Recent progress and major gaps in the vaccine development for African swine fever2024 · 30 citations
  3. 3African Swine Fever: Vaccine Advancement and Major Gaps2026 · 8 citations
  4. 4Progress Toward Development of Effective and Safe African Swine Fever Virus Vaccines2020 · 84 citations
  5. 5Vaccines for African swine fever: an update2023 · 125 citations