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February 21, 2020Frontiers in Veterinary ScienceOpen Access

Live attenuated African Swine Fever Virus vaccines are currently the most promising candidates for eliciting protective immunity, though safety concerns and scale-up issues remain major challenges.

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Population

Pigs (African Swine Fever Virus)

Design

Review

Key result

Live attenuated African Swine Fever Virus vaccines are currently the most promising candidates for eliciting protective immunity, though safety concerns and scale-up issues remain major challenges.

Authors

HSHuldah SangGMGabrielle F. MillerSLShehnaz Lokhandwala

Discussion

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Overview

Prioritizes live attenuated ASFV vaccines for development investment; leaves open resolution of safety and scale-up barriers before field deployment.

Structured PICO

P
Population
Pigs (African Swine Fever Virus)
I
Intervention
African Swine Fever virus vaccines (live attenuated virus, recombinant protein- and DNA-based, and virus-vectored subunit vaccine candidates)

This review summarizes the current progress and strategies in developing effective and safe vaccines against the African Swine Fever virus.

Limitations

  • Safety concerns with live attenuated vaccines
  • Lack of knowledge on appropriate challenge models
  • High costs and space constraints of BSL3 biocontainment laboratories
  • Potential for vaccine-induced disease exacerbation
  • Limitations of challenge models for evaluating ASFV vaccine candidates

Cite This Study

Sang et al. (2020) conducted a review in African swine fever. African Swine Fever Virus Vaccines was evaluated. Live attenuated African Swine Fever Virus vaccines are currently the most promising candidates for eliciting protective immunity, though safety concerns and scale-up issues remain major challenges.

synapsesocial.com/papers/6aade42d19a7e2399000dd99https://doi.org/10.3389/fvets.2020.00084
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Approaches and Perspectives for Development of African Swine Fever Virus Vaccines2017 · 210 citations
  2. 2African Swine Fever: Vaccine Advancement and Major Gaps2026 · 8 citations
  3. 3African Swine Fever Virus as a Difficult Opponent in the Fight for a Vaccine—Current Data2021 · 41 citations
  4. 4Current progress in diagnostics, therapeutics, and vaccines for African swine fever virus2023 · 9 citations
  5. 5Current research progress on the viral immune evasion mechanisms of African swine fever virus2024 · 8 citations