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February 5, 2024Brazilian Journal of MicrobiologyOpen Access

Gene deleted live attenuated vaccines (LAVs) appear to be the most potential vaccine candidates, with ASFV-G-∆I177L being the sole commercially available vaccine.

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Why the study?

African swine fever outbreaks pose a formidable challenge to the global swine industry with limited control options, while vaccine development faces critical gaps in knowledge of viral biology and host immune responses.

Design

Review

Authors

MCManjunatha ChandanaSNSonu S. NairVCVishnu Chaturvedi

Discussion

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Overview

Alerts to expanding ASF outbreaks in swine; leaves open targeted vaccine and control strategies pending trials.

Structured PICO

P
Population
Wild boars and domestic pigs affected by African swine fever virus (ASFV)
I
Intervention
Vaccine development against African swine fever (including inactivated vaccines, subunit vaccines, DNA vaccines, virus-vectored vaccines, and live attenuated vaccines)

This review highlights the progress in ASF vaccine development, identifying gene-deleted live attenuated vaccines as the most promising candidates while noting significant knowledge gaps in ASFV biology.

Limitations

  • critical gaps in the knowledge of ASFV biology and the immune response induced by ASFV infection

Cite This Study

Chandana et al. (2024) studied this question.

synapsesocial.com/papers/6a72395df44fa9f079dfc784https://doi.org/10.1007/s42770-024-01264-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1African Swine Fever: Vaccine Advancement and Major Gaps2026 · 8 citations
  2. 2Vaccines for African swine fever: an update2023 · 125 citations
  3. 3Approaches and Perspectives for Development of African Swine Fever Virus Vaccines2017 · 210 citations
  4. 4Thoughts on the research of African swine fever live-attenuated vaccines2024 · 18 citations
  5. 5Progress Toward Development of Effective and Safe African Swine Fever Virus Vaccines2020 · 84 citations