Why the study?
African swine fever virus causes high mortality in domestic pigs and threatens the global swine industry, but inactivated and subunit vaccine candidates have largely failed to provide effective protection.
The development of ASF vaccines faces enormous biological challenges due to unusual ASFV characteristics such as multiple distinct infectious virions, high glycosylation, and immune evasion.
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ASF vaccine development remains stalled; leaves open novel platforms overcoming virion diversity and immune evasion.
James Zhu (2022) studied this question.
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