Key result
All 30 sequenced African Swine Fever Virus isolates from Vietnam during 2019-2021 belonged to genotype II and shared 100% nucleotide identity with previously identified strains.
Why the study?
This study aimed to identify potential genetic diversity among African swine fever virus strains circulating in central and southern Vietnam.
Observational (n=148)
Yes
ASFV genetic variants in Vietnam support targeted surveillance; leaves open implications for regional control and vaccine matching.
This study aimed to identify potential genetic diversity among African swine fever virus (ASFV) strains circulating in central and southern Vietnam. Thirty ASFV strains were collected from domestic pigs and convalescent pigs with ASFV-infected clinical signs from 19 different provinces of central and southern Vietnam during 2019–2021. A portion of the B646L (p72) gene and the entire E183L (p54), CP204L (p30), and B602L (CVR) genes were amplified, purified, and sequenced. Web-based BLAST and MEGA-X software were used for sequence analysis. Analysis of the partial B646L (p72) gene, the full-length E183L (p54) and CP204L (p30) genes, and the central hypervariable region (CVR) of the B602L gene sequence showed that all 30 ASFV isolates belonged to genotype II and were 100% identical to the previously identified strains in Vietnam and China. Analysis of the p72, p54, and p30 regions did not indicate any change in the nucleotide and amino acid sequences among these strains in 3 years of research. No novel variant was found in the CVR within the B602L gene. Analysis of the CVR showed that these ASFV strains belong to subgroup XXXII. The results of this study revealed that these ASFVs shared high homology with ASFV isolates detected previously in northern Vietnam and China. Taken together, the results of this study and a previous study in Vietnam showed high stability and no genetic diversity in the ASFV genome.
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Nguyen et al. (2021) conducted an observational in African Swine Fever (n=148). African Swine Fever Virus (ASFV) was evaluated on Genetic diversity and genotypic characteristics of ASFV strains. All 30 sequenced African Swine Fever Virus isolates from Vietnam during 2019-2021 belonged to genotype II and shared 100% nucleotide identity with previously identified strains.
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