Key result
African Swine Fever outbreaks in Can Tho involve cocirculating genotype 2 and serotype 8 variants.
Why the study?
African swine fever has caused large socioeconomic consequences in Asian countries, but the genotype, serotype, and genetic variation of viruses responsible for 2019-2022 outbreaks in Can Tho city, Vietnam, needed determination.
Observational
The study identifies the specific genotypes and variants of African Swine Fever virus circulating in Can Tho city, aiding in understanding viral evolution and tracing infection sources.
Supports enhanced molecular surveillance for ASFV in southern Vietnam; leaves open questions on variant-specific control measures.
African swine fever (ASF) is a highly contagious and deadly viral disease in domestic and feral pigs. Since 2018, the disease has spread and caused large socioeconomic consequences to the pig industry in several Asian countries including China, Vietnam, and South Korea. This study aims to determine the genotype, serotype, and genetic variation of representative ASF viruses (ASFV) responsible for the outbreaks in 2019-2022 in Can Tho city, a central administrative province in the Mekong delta, Vietnam. For outbreak investigation, the presence of causative ASFVs was tested using conventional PCR targeting the B646L gene. Subsequently, the amplification and sequencing of the DNA fragments of the putative B646L gene encoding the major capsid protein p72, EP402R gene encoding the viral hemagglutinin CD2-like protein (CD2v), and intergenic region (IGR) between the l73R and I329L genes were performed for molecular characterization. Phylogenetic analyses based on B646L and EP402R genes confirmed that all ASFVs detected in Can Tho city belonged to genotype 2 and serotype 8. In addition, this study revealed that at least two variants of ASFVs, namely, IGR II and IGR III, based on the nucleotide variation of the IGR sequence, cocirculated, and caused outbreaks in Can Tho city. The molecular characterization study provides great significance for understanding the evolution of ASFVs and tracing possible sources of infection in Can Tho and Mekong delta.
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Hiền et al. (2023) conducted an observational in African swine fever. African Swine Fever Viruses (ASFV) was evaluated on Genotype, serotype, and genetic variation of ASFV. African Swine Fever Viruses detected in Can Tho city belonged to genotype 2 and serotype 8, with at least two variants (IGR II and IGR III) cocirculating during the 2019-2022 outbreaks.
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