Spinal cord injury paralysis was associated with a significantly increased risk of in-hospital mortality (OR 2.8) compared to no paralysis in patients with acute myocardial infarction undergoing PCI.
Cohort (n=2,151,994)
Yes
Does spinal cord injury or stroke paralysis affect in-hospital mortality and adverse outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention?
Spinal cord injury paralysis is associated with significantly higher in-hospital mortality and cardiogenic shock in patients undergoing PCI for AMI, highlighting a high-risk population that requires specialized attention, particularly among females.
Odds Ratio: 2.8 (95% CI 1.9–3.9)
Absolute Event Rate: 6.4% vs 2.1%
p-value: p=<0.001
This study aimed to explore the association between two major etiologies of paralysis and the in-hospital outcomes of patients with acute myocardial infarction (AMI) who had undergone percutaneous coronary intervention (PCI). We retrieved AMI patients undergoing PCI from the National Inpatient Sample (2003-2015) and divided them into without paralysis, spinal cord injury (SCI) paralysis, and stroke paralysis. Paralysis' impact on hospital outcomes was explored using multivariate regression. Interaction analysis was used to investigate the sex differences. We observed the temporal trends of in-hospital outcomes from 2003 to 2015 by paralysis etiology. A total of 2,151,994 AMI cases were identified, with 6,711 SCI paralysis and 8,322 stroke paralysis. Compared to patients without paralysis, patients with SCI but not stroke paralysis had increased rates of in-hospital mortality (odds ratio OR: 2.8, 95% confidence interval CI: 1.9-3.9), cardiogenic shock (OR: 2.4, 95% CI: 1.8-3.3). Furthermore, this positive association between SCI and in-hospital adverse outcomes is more significant in females than males. In conclusion, SCI paralysis is associated with an increased risk of in-hospital mortality, cardiogenic shock in patients with AMI undergoing PCI, especially in females. These disparities lasted from 2003 to 2015.
Qi et al. (Fri,) conducted a cohort in Acute myocardial infarction (n=2,151,994). Spinal cord injury (SCI) paralysis vs. No paralysis was evaluated on In-hospital mortality (OR 2.8, 95% CI 1.9-3.9, p=<0.001). Spinal cord injury paralysis was associated with a significantly increased risk of in-hospital mortality (OR 2.8) compared to no paralysis in patients with acute myocardial infarction undergoing PCI.