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March 8, 2026Stem Cell ReportsOpen Access

Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells

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Authors

KZKe ZhangHLHuilin LiangSCShuyi Chen

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Overview

This research demonstrates Mettl3's role in axonogenesis and neuronal fate reprogramming, suggesting implications for neurodegeneration therapies.

Key Points

  • To investigate the role of Mettl3 and m6A modifications in the reprogramming of retinal ganglion cells.
  • Used induced retinal ganglion cell-like neuron system for experimentation.
  • Conducted RNA-seq and MeRIP-seq analyses to examine m6A modifications.
  • Identified key genes modified by m6A that mediate the effects of Mettl3.
  • Mettl3 significantly promoted iRGC fate reprogramming.
  • Dynamic m6A modifications were observed during iRGC reprogramming.
  • Three m6A-modified genes were identified as critical mediators of Mettl3's effects.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69ada804bc08abd80d5bb2b4https://doi.org/10.1016/j.stemcr.2026.102851
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1m6A methylation regulates RNA axonal localisation and translation in developing neurons2025
  2. 2Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis2025 · 5 citations
  3. 3METTL3 uncouples chromatin accessibility from transcription during retinal development2025 · 1 citations
  4. 4METTL3 Uncouples Chromatin Accessibility from Transcription during Retinal Development2025
  5. 5The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy2026 · 1 citations