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March 8, 2026

SCORTEN and Novel Prognostic Markers in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Systematic Review and Meta-Analysis.

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Authors

ZLZhao Feng LiuHYHao YangLLLawrence O. Lin

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Overview

Systematic review evaluates SCORTEN and identifies blood biomarkers predicting mortality in adults with SJS/TEN, highlighting implications for treatment.

Key Points

  • To assess the predictive accuracy of SCORTEN score and identify additional biomarkers for mortality in SJS/TEN patients.
  • Conducted a systematic review and meta-analysis of relevant studies from Medline, Embase, and Cochrane Library.
  • Included 45 studies with a total of 3467 adult patients diagnosed with SJS/TEN.
  • Used a random-effects model for pooled analyses and assessed the quality of eligible studies.
  • All seven SCORTEN variables were significantly linked to in-hospital mortality.
  • Elevated serum creatinine was independently associated with an increased risk of death.
  • Other potential biomarkers were identified, but insufficient data prevented pooled analysis.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69ada8a1bc08abd80d5bbd2fhttps://doi.org/10.1111/ajd.70082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the Factors Influencing Mortality in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Multicenter Study of 166 Patients2024 · 9 citations
  2. 245 Utility of the Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) in Pediatric Stevens-Johnson Syndrome Patients2024
  3. 3Utility of the Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) in Pediatric Stevens-Johnson Syndrome Patients2024 · 3 citations
  4. 4Prognostic significance of the Systemic Immune-Inflammation Index in Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) patients2024 · 1 citations
  5. 5Incidence and Factors Associated With In-Hospital Mortality in Adult Patients With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Nationwide Thai Cohort2026