Preclinical investigation demonstrates that Ling-Gui-Zhu-Gan decoction reduces doxorubicin cardiotoxicity in cardiomyocytes, suggesting a therapeutic strategy targeting ferroptosis.
LGZGD can ameliorate DOX-cardiotoxicity by activating the Nrf2 signaling pathway and inhibiting ferroptosis in cardiomyocytes.
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Yang et al. (2024) studied this question.
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