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Efficient reaction forms C─C bonds in derivatives using para-quinone methides and cyano acetylpiperidine, indicating broad application potential.
An efficient 1,6‐conjugate addition reaction of para ‐Quinone methides and cyano acetylpiperidine or cyanoacetylmorpholine to form a C─C bond for the synthesis of 3,3‐diaryl‐2‐(piperidine‐1‐carbonyl)propanenitrile and 3,3‐diaryl‐2‐(morpholine‐4‐carbonyl) propanenitrile derivatives was reported in the presence of Et 3 N as a catalyst. This protocol features advantages such as broad substrate scopes, good tolerance of functional groups, and excellent yields.
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TONG et al. (2026) studied this question.
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