What question did this study set out to answer?

To determine whether lowering plasma lipid levels can halt the progression of early aortic valve disease in hypercholesterolemic mice.

May 12, 2009CirculationOpen Access

Lowering Plasma Cholesterol Levels Halts Progression of Aortic Valve Disease in Mice

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Why the study?

Does genetic inactivation of the mttp gene halt the progression of aortic valve stenosis in hypercholesterolemic mice with early aortic valve disease?

Population

hypercholesterolemic mice with early aortic valve disease

Design

Preclinical

Authors

JMJordan D. MillerStructural Heart Disease RWRobert M. WeissGeneral Cardiology KSKristine M. SerranoUniversity of Iowa

Discussion

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Implication

Hypothesis-generating for mttp-targeted therapy in aortic valve stenosis; leaves open translation to patients.

Key Points

To determine whether lowering plasma lipid levels can halt the progression of early aortic valve disease in hypercholesterolemic mice.
Genetically inactivated the microsomal triglyceride transfer protein (mttp) gene to reduce plasma lipid levels in hypercholesterolemic mice exhibiting early aortic valve disease.
Assessed changes in oxidative stress, pro-osteogenic signaling pathways, and aortic valve stenosis progression following lipid reduction.
Genetic inactivation of mttp normalized oxidative stress levels in mice with early aortic valve disease.
Lipid reduction suppressed pro-osteogenic signaling pathways within valve tissues.
Lowering plasma cholesterol halted the structural and functional progression of aortic valve stenosis.

Structured PICO

Does genetic inactivation of the mttp gene halt the progression of aortic valve stenosis in hypercholesterolemic mice with early aortic valve disease?

Population

hypercholesterolemic mice with early aortic valve disease

Intervention

genetic inactivation of the mttp gene to reduce plasma lipid levels

Outcome

progression of aortic valve stenosissurrogate

Reducing plasma lipid levels via mttp gene inactivation halts the progression of early aortic valve disease in a preclinical mouse model.

Cite This Study

Miller et al. (2009) studied this question.

synapsesocial.com/papers/69b31ef095ae609a7965019e https://doi.org/10.1161/circulationaha.108.834614

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Lowering Plasma Cholesterol Levels Halts Progression of Aortic Valve Disease in Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Lowering Plasma Cholesterol Levels Halts Progression of Aortic Valve Disease in Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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