Does genetic inactivation of the mttp gene halt the progression of aortic valve stenosis in hypercholesterolemic mice with early aortic valve disease?
Reducing plasma lipid levels via mttp gene inactivation halts the progression of early aortic valve disease in a preclinical mouse model.
Collectively, these data indicate that reducing plasma lipid levels by genetic inactivation of the mttp gene in hypercholesterolemic mice with early aortic valve disease normalizes oxidative stress, reduces pro-osteogenic signaling, and halts the progression of aortic valve stenosis.
Miller et al. (Tue,) studied this question.