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March 13, 2026PLoS PathogensOpen Access

Conserved non-coding RNA motifs influence the neuropathogenicity of Simbuviruses: Molecular dissection in the Schmallenberg virus model

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Authors

LBLaura BonilUniversity of NamurLWLaetitia WiggersUniversity of NamurHDHélène DumontUniversity of Namur

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Implication

This research investigates the role of RNA motifs in viral neuropathogenicity, suggesting implications for understanding Simbuviruses.

Key Points

  • The study aims to explore how conserved non-coding RNA motifs impact the neuropathogenicity of Simbuviruses.
  • Developed a viral recombinant library with mutations in RNA motifs.
  • Evaluated replication kinetics and protein synthesis in cell culture.
  • Assessed virulence in a mouse model to quantify viral loads and survival rates.
  • The stem-loop structure is crucial for viral production; stem length affects replication fitness.
  • Mutations in the GC signal disrupt mRNA termination and reduce N protein synthesis.
  • Attenuated viruses showed lower viral loads and improved survival in mice compared to wild-type.

Cite This Study

Bonil et al. (2026) studied this question.

synapsesocial.com/papers/69b3ab2902a1e69014ccbdaehttps://doi.org/10.1371/journal.ppat.1014006
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