Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 13, 2026Seminars in OncologyOpen Access

Cancer-Associated Fibroblasts in Bladder Cancer: Immunosuppressive Mechanisms and Therapeutic Targeting

View Full Paper
Ask AI
Bookmark
Share

Authors

YLYi LiuTZTianyu ZhaoRSRun Shi

Discussion

Loading...

Member takes

Overview

This review examines CAF roles in immune evasion in bladder cancer, suggesting new therapeutic strategies.

Key Points

  • This review aims to elucidate the role of cancer-associated fibroblasts in regulating the immune response in bladder cancer and explore therapeutic targeting strategies.
  • Reviewed current literature on cancer-associated fibroblasts (CAFs) in bladder cancer.
  • Analyzed findings from single-cell analysis and spatial transcriptomics regarding CAF heterogeneity.
  • Integrated data on cytokine signaling networks and CAF-mediated mechanisms.
  • Discussed current therapeutic strategies targeting CAFs.
  • Identified distinct CAF subtypes that influence T cell activity and treatment responses.
  • Revealed that CAFs contribute to immune exclusion and resistance to standard therapies.
  • Highlighted the potential of combining therapies to overcome the challenges posed by the tumor microenvironment.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b3abc502a1e69014ccceedhttps://doi.org/10.1016/j.seminoncol.2026.152483
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting cancer-associated fibroblasts as a therapeutic strategy to improve immune checkpoint blockade therapy2026
  2. 2Heterogeneity of Cancer‐Associated Fibroblasts and Precision Targeting Strategies for Cancer Therapy2026
  3. 3Cancer-associated fibroblast targeting therapies as a tool to enhance responses to radiotherapy and immunotherapy2026 · 2 citations
  4. 4Cancer-Associated Fibroblasts: Immunosuppressive Crosstalk with Tumor-Infiltrating Immune Cells and Implications for Therapeutic Resistance2025 · 34 citations
  5. 5Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics analysis2025