What question did this study set out to answer?

To evaluate the effects of sublethal clothianidin exposure on development, thyroid hormone regulation, and behavior in Fejervarya cancrivora tadpoles.

March 13, 2026ToxicsOpen Access

Sublethal Clothianidin Exposure Impairs Development, Thyroid Hormones, Locomotion and Predation in Fejervarya cancrivora from Rice Paddy Ecosystems

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Authors

JPJoko PiliantoUniversity of Brawijaya AEAmr Abou El-ElaMinistry of Agriculture AMAsim MunawarMinistry of Agriculture and Rural Affairs

Discussion

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Implication

Acute toxicity tests reveal CLO impairs development and predation in amphibians, implying risks to biodiversity.

Key Points

To evaluate the effects of sublethal clothianidin exposure on development, thyroid hormone regulation, and behavior in Fejervarya cancrivora tadpoles.
Conducted acute toxicity tests to determine LC50 and other concentrations
Assessed impact on body weight, length, and limb development during metamorphosis
Evaluated thyroid hormone levels, specifically T3 and T4
Measured locomotor activity by analyzing swimming distance and speed
Tested feeding efficiency on brown planthoppers in frogs developed from exposed tadpoles
Determined an LC50 of 50.41 mg a.i./L for clothianidin
Observed significant reductions in body weight and whole-body length
Reported altered thyroid hormone levels, with a dose-dependent increase in T4
Noted impaired swimming distance and speed in CLO-exposed tadpoles
Found decreased feeding efficiency on brown planthoppers in frogs from CLO-exposed tadpoles

Cite This Study

Pilianto et al. (2026) studied this question.

synapsesocial.com/papers/69b3abf602a1e69014ccd374 https://doi.org/10.3390/toxics14030243

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