What does this research mean for the field?

Dietary supplementation with Bacillus amyloliquefaciens partially mitigates clothianidin-induced growth inhibition and liver oxidative injury in goslings by regulating redox homeostasis, lipid and energy metabolism, and liver metabolic remodeling. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether dietary supplementation with Bacillus amyloliquefaciens alleviates growth inhibition and liver oxidative stress caused by clothianidin exposure in goslings.

September 2, 2026AntioxidantsOpen Access

Bacillus amyloliquefaciens Alleviates Clothianidin-Induced Liver Oxidative Stress and Growth Suppression in Goslings

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Authors

GLGuangquan Li KWKaiqi Weng YLYi Liu

Discussion

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Overview

Controlled trial shows Bacillus amyloliquefaciens reduces clothianidin-induced liver damage and growth suppression in goslings, highlighting its potential to counteract pesticide toxicity.

Key Points

To determine whether dietary supplementation with Bacillus amyloliquefaciens alleviates growth inhibition and liver oxidative stress caused by clothianidin exposure in goslings.
Assigned 14-day-old Holdobagy goslings to five dietary treatments for 21 days: control, 2.5 mg/kg clothianidin (CLO), 2.5 mg/kg CLO plus 60 ppm Bacillus amyloliquefaciens (BA), 10 mg/kg CLO, and 10 mg/kg CLO plus 60 ppm BA.
Evaluated growth traits, liver index, serum biochemical markers (AKP, AST), oxidative stress indices (MDA, T-AOC, SOD), and liver histopathology.
Conducted serum untargeted metabolomics and liver transcriptomics to identify altered metabolic pathways and differentially expressed genes across treatment groups.
Clothianidin exposure significantly suppressed final body weight and average daily gain, increased liver index, elevated serum AKP, AST, and MDA, and lowered liver T-AOC and SOD activities (p < 0.05).
Dietary BA supplementation alleviated CLO-induced liver lesions, including hepatocyte disorganization, vacuolar degeneration, congestion, and inflammatory cell infiltration.
BA reversed the disruption of 115 and 170 serum metabolites and modulated 338 and 440 liver differentially expressed genes under low- and high-dose CLO exposures, respectively (p < 0.05), primarily targeting glutathione, PPAR, and fatty acid metabolism.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a97e25ec562ede874ec66db https://doi.org/10.3390/antiox15091092

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September 2, 2026AntioxidantsOpen Access

Bacillus amyloliquefaciens Alleviates Clothianidin-Induced Liver Oxidative Stress and Growth Suppression in Goslings

View Full Paper

Ask AI

Bookmark

Authors

GLGuangquan Li KWKaiqi Weng YLYi Liu

Discussion

Member takes

Overview

Controlled trial shows Bacillus amyloliquefaciens reduces clothianidin-induced liver damage and growth suppression in goslings, highlighting its potential to counteract pesticide toxicity.

Key Points

To determine whether dietary supplementation with Bacillus amyloliquefaciens alleviates growth inhibition and liver oxidative stress caused by clothianidin exposure in goslings.
Assigned 14-day-old Holdobagy goslings to five dietary treatments for 21 days: control, 2.5 mg/kg clothianidin (CLO), 2.5 mg/kg CLO plus 60 ppm Bacillus amyloliquefaciens (BA), 10 mg/kg CLO, and 10 mg/kg CLO plus 60 ppm BA.
Evaluated growth traits, liver index, serum biochemical markers (AKP, AST), oxidative stress indices (MDA, T-AOC, SOD), and liver histopathology.
Conducted serum untargeted metabolomics and liver transcriptomics to identify altered metabolic pathways and differentially expressed genes across treatment groups.
Clothianidin exposure significantly suppressed final body weight and average daily gain, increased liver index, elevated serum AKP, AST, and MDA, and lowered liver T-AOC and SOD activities (p < 0.05).
Dietary BA supplementation alleviated CLO-induced liver lesions, including hepatocyte disorganization, vacuolar degeneration, congestion, and inflammatory cell infiltration.
BA reversed the disruption of 115 and 170 serum metabolites and modulated 338 and 440 liver differentially expressed genes under low- and high-dose CLO exposures, respectively (p < 0.05), primarily targeting glutathione, PPAR, and fatty acid metabolism.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a97e25ec562ede874ec66db https://doi.org/10.3390/antiox15091092

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