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March 13, 2026Scientific ReportsOpen Access

Mechanism of action of Astragalus membranaceus for treating diabetic foot ulcers based on single-cell RNA sequencing data and network pharmacology

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Authors

XLXia LiYDYi DongCHChong Huang

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Overview

Explores how Astragalus membranaceus affects diabetic foot ulcer healing through cellular mechanisms.

Key Points

  • This research investigates the molecular mechanisms by which Astragalus membranaceus may aid in the healing of diabetic foot ulcers.
  • Integrated single-cell RNA sequencing data from a public cohort with network pharmacology analysis.
  • Analyzed samples from 4 non-diabetic foot ulcer and 5 diabetic foot ulcer cases.
  • Identified 14 active compounds in Astragalus membranaceus and their predicted molecular targets.
  • Performed qPCR validation on candidate hub genes using samples from a clinical cohort.
  • Discovered significant macrophage heterogeneity in diabetic foot ulcer microenvironment.
  • Identified strong binding affinities between Astragalus membranaceus compounds and macrophage-associated hub genes.
  • Confirmed differential expression of several candidate hub genes in diabetic foot ulcer samples compared to non-diabetic foot ulcers.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69b3aca302a1e69014cce7c9https://doi.org/10.1038/s41598-026-41921-5
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