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This research aims to explore the anti-tumor mechanisms of lotus-derived alkaloids in breast cancer.

March 14, 2026MoleculesOpen Access

Molecular Mechanisms Underlying the Anti-Tumor Activity of Lotus-Derived Alkaloids in Breast Cancer

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Research demonstrates anti-tumor activity of lotus-derived alkaloids in breast cancer, highlighting apoptosis induction and cell cycle arrest.

This research aims to explore the anti-tumor mechanisms of lotus-derived alkaloids in breast cancer.
Systematic investigation of LIE, ISO, and NEF across multiple breast cancer cell lines
Focus on highly aggressive triple-negative breast cancer models
Utilized transcriptomic profiling and molecular analysis
Potent growth-inhibitory effects observed through apoptosis induction
Cell cycle arrest noted at G1 and G2/M phases
LIE identified as a principal effector in transcriptional reprogramming
Targeting of MAPK and mTOR pathways highlighted as core mechanisms

He et al. (2026) studied this question.

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Research demonstrates anti-tumor activity of lotus-derived alkaloids in breast cancer, highlighting apoptosis induction and cell cycle arrest.