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March 15, 2026Journal of Fish Diseases

Integrated Transcriptomic and Proteomic Analysis Reveals the Immune Response of Largemouth Bass ( Micropterus salmoides ) to Aeromonas hydrophila Infection

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Authors

FCFuyan ChenSWShuiping WenXHXuehai He

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Overview

Integrated analysis reveals immune biomarkers in largemouth bass after Aeromonas hydrophila infection, suggesting novel prevention strategies.

Key Points

  • This research aims to elucidate the immune response of largemouth bass to Aeromonas hydrophila infection through transcriptomic and proteomic analysis.
  • Used integrated transcriptomic and proteomic approaches
  • Analyzed liver response at 72 hours post-infection via intraperitoneal injection
  • Identified differentially expressed genes (2136 upregulated, 200 downregulated) and proteins (1683 upregulated, 1817 downregulated)
  • Upregulated DEGs/DEPs are involved in immune pathways like TNF signalling and B cell receptor signalling
  • Downregulated DEGs/DEPs largely relate to lipid metabolism
  • Identified eight key immune-related biomarkers, including complement components and MYD88

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff4f83145bc643d1b88dhttps://doi.org/10.1111/jfd.70165
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