Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 7, 2026International Journal of Molecular SciencesOpen Access

An Integrative ATAC-Seq and RNA-Seq Analysis of Spleen Tissues from Largemouth Bass (Micropterus salmoides) Infected with Iridovirus (LMBV)

View Full Paper
Ask AI
Bookmark
Share

Authors

HSHan SunJHJixiang HuaYTYifan Tao

Discussion

Loading...

Member takes

Overview

Randomized trial analyzes chromatin and transcription changes in largemouth bass after LMBV infection, suggesting epigenetic markers for breeding.

Key Points

  • The research aims to investigate chromatin accessibility and gene expression changes in largemouth bass in response to iridovirus infection.
  • Largemouth bass were classified as resistant or susceptible based on survival after LMBV infection.
  • ATAC-seq and RNA-seq were used to analyze chromatin accessibility and transcriptome changes in spleen tissues.
  • Functional and motif enrichment analyses identified key transcription factors and immune-related genes.
  • Identified 11,317 differentially accessible regions between resistant and susceptible bass groups.
  • Core promoter regions showed increased chromatin accessibility in the resistant group, indicating a role in immune regulation.
  • Seventy-one candidate genes were identified, with three immune-related genes (irf4a, btk, nfil3-2) linked to transcription factor regulation.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c718b49bacb8b347f80https://doi.org/10.3390/ijms27094124
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome-Wide Association Study of Resistance to Largemouth Bass Ranavirus (LMBV) in Micropterus salmoides2024 · 14 citations
  2. 2Chromatin accessibility and differentially expressed genes profiling in large yellow croaker (Larimichthys crocea) head kidney cells following iridovirus infection2025 · 4 citations
  3. 3Differentiation of Cytopathic Effects (CPE) induced by influenza virus infection using deep Convolutional Neural Networks (CNN)2020 · 25 citations
  4. 4Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection2020 · 30 citations
  5. 5THE ROLE OF THE SPLEEN IN IMMUNITY1966 · 121 citations