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March 15, 2026Life Science AllianceOpen Access

Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs

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Authors

AKAthanasios P. KyritsisRBRafailia AA BetaDSDiana Scutelnic

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Overview

Experimental findings reveal that PARN and miR-29a interplay affects degradation and cell migration in lung cancer.

Key Points

  • This research explores the feedback regulation between PARN and miR-29a in lung cancer cells.
  • Analyzed the expression of miRNAs in NCI-H520 lung cancer cells
  • Investigated the role of PARN in regulating poly(A) lengths of miRNAs
  • Examined effect of PARN and miR-29a on cell migration
  • PARN regulates the expression of miR-29a and miR-1207 in lung cancer cells
  • Mutations in miR-29a and PARN influence target mRNA degradation
  • Alterations in PARN or miR-29a expression impact cell migration.

Cite This Study

Kyritsis et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff4f83145bc643d1ba02https://doi.org/10.26508/lsa.202503341
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