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June 26, 2026Wiley Interdisciplinary Reviews - RNAOpen Access

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

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Authors

SFSujitha FelicitusSPShalon Suzanne PintoSRSai Samanvitha Madagundapalli Ramakrishna

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Overview

Review examines molecular interactions between PARN and telomerase in disease development, suggesting emerging therapeutic strategies.

Key Points

  • This review explores how PARN and telomerase work together in cellular processes and the consequences of their dysfunction in diseases.
  • Reviewed existing literature on PARN and telomerase interactions
  • Analyzed the role of pathogenic variations in related diseases
  • Discussed emerging therapeutic strategies targeting these molecular pathways
  • Pathogenic variations in PARN and telomerase genes lead to diseases like bone marrow failure and neoplastic ailments.
  • Defects in p53 signaling aggravate telomere shortening and disrupt PARN activity, promoting cancer.
  • Targeting the pathways regulated by PARN and telomerase shows promise for therapeutic interventions.

Cite This Study

Felicitus et al. (2026) studied this question.

synapsesocial.com/papers/6a3e176b030ad1a9b3090e82https://doi.org/10.1002/wrna.70049
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