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March 17, 2026Current Pharmaceutical Design

Dual-Targeted Antiemetic Strategy: A Review of Granisetron-Scopolamine Transdermal Patch for PONV and CINV Management

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Authors

ASAshim Kumar SarkarKSKamal ShahHDHitesh Kumar Dewangan

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Overview

Review reveals a granisetron-scopolamine patch enhances antiemetic effectiveness in postoperative and chemotherapy-induced nausea, indicating improvement in patient outcomes.

Key Points

  • This review examines the effectiveness of a granisetron-scopolamine transdermal patch for managing PONV and CINV.
  • Review existing literature on antiemetic therapies for PONV and CINV
  • Analyze the combined pharmacological effects of granisetron and scopolamine
  • Evaluate transdermal delivery advantages for medication adherence and symptom control.
  • Combination of granisetron and scopolamine may improve nausea control compared to monotherapy.
  • Transdermal patch enhances patient adherence and reduces discomfort associated with oral medications.
  • Existing studies suggest that dual-targeted therapy may provide superior efficacy for managing nausea.

Cite This Study

Sarkar et al. (2026) studied this question.

synapsesocial.com/papers/69b8f11edeb47d591b8c5fe0https://doi.org/10.2174/0113816128416291251201042848
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Granisetron for Postoperative Nausea and Vomiting Prophylaxis in Microvascular Decompression Despite Prominent Non-serotonergic Emetic Pathways2026
  2. 2Comparative Efficacy of Palonosetron–Dexamethasone Versus Granisetron–Dexamethasone for Prevention of Postoperative Nausea and Vomiting: A Review With Focus on Otologic Surgeries2026
  3. 3Evaluation of granisetron as an antiemetic in patients undergoing abdominal hysterectomy under spinal anaesthesia2017 · 3 citations
  4. 4Development and pharmacokinetic evaluation of granisetron hydrochloride buccal tablets for optimized chemotherapy-induced nausea and vomiting (CINV) relief2026 · 1 citations
  5. 5A RESEARCH ON "FORMULATION AND EVALUATION OF TRANDERMAL PATCH OF ONDANSETRON HYDROCHLORIC ACID (HCL)"2026