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July 15, 2026CureusOpen Access

Granisetron for Postoperative Nausea and Vomiting Prophylaxis in Microvascular Decompression Despite Prominent Non-serotonergic Emetic Pathways

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Authors

HOHiroyuki OishiTKTakenori KatoNHNobuaki Hagiwara

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Overview

Exploratory study shows granisetron reduces postoperative nausea and vomiting in microvascular decompression, suggesting further investigation is needed.

Key Points

  • This study aims to evaluate the effectiveness of granisetron in preventing postoperative nausea and vomiting after microvascular decompression, considering alternative emetic pathways.
  • Retrospective, exploratory, quasi-experimental before-after design
  • Included 40 MVD patients (20 granisetron group, 20 control group)
  • Primary outcomes measured were PONV incidence, nausea severity, vomiting episodes, and rescue antiemetic use.
  • Granisetron group had a 24-hour PONV incidence of 35% compared to 80% in the control group, with an ARR of 45% and RRR of 56% (p=0.010)
  • Nausea severity was significantly lower in the granisetron group at six hours (4.0 vs. 8.5; p=0.002)
  • Granisetron group experienced fewer vomiting episodes (0 vs. 1; p=0.022).

Cite This Study

Oishi et al. (2026) studied this question.

synapsesocial.com/papers/6a5723c288b21df8754805b3https://doi.org/10.7759/cureus.112568
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