Key result
Granisetron reduces postoperative nausea and vomiting ~29% versus droperidol after open cholecystectomy.
Why the study?
Postoperative nausea and vomiting remain frequent despite prophylactic use of conventional antiemetics, necessitating evaluation of more effective prevention strategies.
Does granisetron reduce postoperative nausea and vomiting compared to droperidol in adult patients undergoing elective open cholecystectomy?
RCT (n=100)
Double-blind
randomly allocated
Does granisetron reduce postoperative nausea and vomiting compared to droperidol in adult patients undergoing elective open cholecystectomy?
Absolute Event Rate: 54% vs 76%
p-value: p=0.022
Granisetron is superior to droperidol in preventing postoperative nausea and vomiting following open cholecystectomy.
Granisetron may offer better PONV control than droperidol post-cholecystectomy; leaves open need for larger trials before practice change.
BACKGROUND: Post operative nausea and vomiting (PONV) continue to be frequent occurrences, even when conventional antiemetics are prophylactically used. OBJECTIVE: To compare the efficacy of Granisetron over Droperidol in the prevention of PONV in patients undergoing elective open cholecystectomy under general anesthesia. MATERIAL & METHODS: In this double blind randomized study, 100 adult patients with physical status ASA I and II, (age, 20-60 years), were randomly allocated into two groups, X or Y, to receive either injection Granisetron hydrochloride (3 mg i/v) or Droperidol (2.5 mg i/v), 5 min prior to induction of general anesthesia. The incidence of nausea and vomiting was recorded every six hourly for a period of 24 hour after the surgery. RESULTS: 6 (12%) patients in the granisetron group and 20 (40%) patients in the Droperidol group reported an emetic episode, (p = 0.002); the incidence of PONV in the total 24 hr period after the surgery, 54% in the granisetron group and 76% in Droperidol group (p = 0.022) CONCLUSIONS: It was found that granisetron is superior to Droperidol in the prevention of postoperative nausea and vomiting. JMS 2011;14(1):11-14
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Lone et al. (2011) conducted an RCT in Postoperative Nausea and Vomiting (PONV) (n=100). Granisetron vs. Droperidol (2.5 mg i/v) was evaluated on Incidence of postoperative nausea and vomiting (PONV) in the total 24 hour period after surgery (p=0.022). Granisetron was superior to droperidol in preventing postoperative nausea and vomiting over 24 hours following open cholecystectomy (54% vs 76%; p=0.022).
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