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March 13, 2026

Bronchoalveolar lavage fluid KL-6 and SP-D levels in relation to fibrotic features of interstitial lung disease.

Shuya Miyazaki Naoyuki Kuse Minoru Inomata Nobuyasu Awano KEITA SAKAMOTO Kosaku Komiya Takehiro Izumo

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Key Points

This research aims to explore the relationship between KL-6 and SP-D levels in bronchoalveolar lavage fluid and the presence of fibrosis in interstitial lung disease.
Measured BALF levels of KL-6 and SP-D
Calculated BALF/serum ratios of KL-6 and SP-D
Evaluated correlations with fibrosis using HRCT results
KL-6 and SP-D levels show a negative correlation with the presence of fibrosis.
Biomarker levels remain predictive even when fibrosis is not visible on HRCT.

Implication

Finds predictive correlations of KL-6 and SP-D levels with fibrosis in interstitial lung disease, suggesting diagnostic potential.

Discussion

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Cite This Study

Miyazaki et al. (2026) studied this question.

synapsesocial.com/papers/69b8f12fdeb47d591b8c6208 https://doi.org/10.1016/j.resinv.2026.101404

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