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April 25, 2026˜La œMedicina del lavoro0 citationsOpen Access

Diagnostic Utility of Serum Krebs von den Lungen-6 (KL-6) and Surfactant Protein-D (SP-D) Levels in Hypersensitivity Pneumonitis

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AKAsuman Aslan KaraAKAdem KoyuncuGSGülden Sarı

Key Points

  • This research aims to determine the effectiveness of KL-6 and SP-D as biomarkers for diagnosing hypersensitivity pneumonitis (HP) and monitoring treatment.
  • Evaluated serum levels of KL-6 and SP-D in patients with hypersensitivity pneumonitis.
  • Analyzed the relationship between biomarker levels and disease activity.
  • Compared efficacy of KL-6 and SP-D in reflecting fibrotic progression.
  • KL-6 demonstrated high sensitivity for diagnosing hypersensitivity pneumonitis.
  • SP-D showed some correlation with inflammatory processes but had limitations in assessing fibrotic changes.
  • KL-6 levels were valuable for monitoring treatment response in HP.

Abstract

KL-6 emerges as a sensitive biomarker in the diagnosis of HP, assessing of disease activity, and monitoring treatment response. SP-D, although reflecting inflammatory processes, seems to be have limitations in evaluating fibrotic progression.

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Cite This Study

Kara et al. (2026) studied this question.

synapsesocial.com/papers/69ec598788ba6daa22dab66chttps://doi.org/10.23749/mdl.2026.18283
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