Research on the effect of Fructus Lycii Ruthenic and Herba Cistanches on senile osteoporosis in aged rats via regulation of the PI3K/Akt signaling pathway

February 1, 2026Lishizhen medicine and materia medica research

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This research explores the impact of Fructus Lycii and Herba Cistanches on senile osteoporosis in aged rats through modulation of the PI3K/Akt signaling pathway.
48 SD rats were divided into several groups including a control and treatment groups.
Micro-CT assessed bone microstructure changes in the treated rats.
HE staining analyzed femur pathology, while alkaline phosphatase staining measured osteoblast activity.
TRAP staining assessed osteoclast activity, and ELISA measured serum TNF-α, BALP, and TRACP-5b levels.
Western blot analyzed the expression of PI3K/Akt pathway proteins in femur tissue.
Compared to the control group, aged rats showed significant degradation in bone microstructure and decreased BMD/PV/TV, Tb.N, and Tb.Th values (P<0.05).
The treatment group exhibited improvements in these parameters and reduced pathological damage (P<0.05).
Rats treated with 740 Y-P showed trends opposite to the treatment group, suggesting its counteractive effects.

Research shows improvements in osteoporosis in aged rats with treatment, indicating potential therapeutic benefits.

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FENG et al. (2026) studied this question.

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