Regulatory effects of icariin on the LPS-induced inflammatory response, autophagy, and fibrosis in synovial fibroblasts

September 1, 2025Lishizhen medicine and materia medica research

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Key Points

This research analyzes how icariin regulates inflammatory responses, autophagy, and fibrosis in synovial fibroblasts induced by LPS.
Treatment with various concentrations of icariin and LPS in synovial fibroblast cultures.
Assessment of cell proliferation using MTT assay and measurement of inflammatory cytokines via ELISA.
Analysis of autophagy and fibrosis markers using Western blotting.
Compared to the control, inflammatory cytokines IL-1β, TNF-α, and IL-6 significantly increased in the model group (P<0.05).
Icariin and YY-20394 treatment groups demonstrated a decrease in inflammatory cytokines and protein expression levels compared to the model group (P<0.05).
The combination of icariin and YY-20394 significantly reduced both cytokines and associated protein expressions (P<0.05).

Investigates icariin's effects on inflammation and fibrosis in fibroblasts, suggesting therapeutic potential.

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YUAN et al. (2025) studied this question.

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