Key result
ARNI initiation linked to hypotension in ~27% of acute decompensated heart failure patients during rehabilitation.
Why the study?
To examine hypotension during cardiac rehabilitation after ARNI initiation in patients with acute decompensated heart failure and its clinical characteristics.
Does ARNI initiation cause hypotension that affects the feasibility of early cardiac rehabilitation in patients with acute decompensated heart failure?
Observational (n=124)
Does ARNI initiation cause hypotension that affects the feasibility of early cardiac rehabilitation in patients with acute decompensated heart failure?
Initiation of ARNI in acute decompensated heart failure frequently causes early hypotension that can hinder cardiac rehabilitation, especially in patients with low baseline blood pressure and high BNP.
Answers are grounded in this paper and cite their sources.
May limit early cardiac rehabilitation feasibility after ARNI in acute decompensated heart failure; hypothesis-generating for risk stratification and protocol adjustments.
Background: To examine hypotension during cardiac rehabilitation (CR) after angiotensin receptor-neprilysin inhibitor (ARNI) initiation in patients with acute decompensated heart failure (ADHF) and its clinical characteristics. Methods and Results: We studied 124 ADHF patients who received ARNI (2022-2023). During CR, 26.6% had systolic blood pressure (SBP) <90 mmHg; 54.5% experienced interruption or difficulty mobilizing. ARNI were discontinued because of hypotension in 24.2% of patients. Logistic regression revealed low preARNI SBP and high B-type natriuretic peptide (BNP) levels as predictors. Conclusions: Low SBP during CR after ARNI use occurred in 26.6% of patients and was associated with low preARNI SBP and high BNP levels.
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Ando et al. (2026) conducted an observational in Acute decompensated heart failure (ADHF) (n=124). Angiotensin receptor-neprilysin inhibitor (ARNI) initiation vs. Unexposed/Reference (Non-low SBP group for predictor analysis) was evaluated on Systolic blood pressure (SBP) <90 mmHg during cardiac rehabilitation within 5 days after ARNI initiation. Among patients with acute decompensated heart failure, 26.6% developed systolic blood pressure <90 mmHg during early cardiac rehabilitation after ARNI initiation.
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