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March 20, 2023CureusOpen Access

Comparison of Efficacy and Safety of Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure With Reduced Ejection Fraction: A Meta-Analysis

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Why the study?

The meta-analysis was conducted to compare the safety and efficacy of ARNI with ARBs and ACEi in patients with heart failure with reduced ejection fraction.

Does treatment with ARNI improve clinical outcomes and ejection fraction in patients with HFrEF compared to ACEi or ARBs?

Population

Patients with HFrEF across 10 included studies

Comparison

ARNI vs ARBs and ACEi

Design

Systematic review and meta-analysis

Authors

MHMuhammad Talha HaseebMAMuhammad Nouman AslamFAFNU Avanteeka

Discussion

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Member takes

Overview

ARNI lowers mortality versus ACEi/ARB in HFrEF; reinforces first-line use despite higher hypotension.

Structured PICO

Does treatment with ARNI improve clinical outcomes and ejection fraction in patients with HFrEF compared to ACEi or ARBs?

P
Population
Patients with heart failure with reduced ejection fraction (HFrEF) from 10 included studies
I
Intervention
Angiotensin receptor-neprilysin inhibitor (ARNI)
C
Comparator
Angiotensin receptor blockers (ARBs) and angiotensin-converting-enzyme inhibitors (ACEi)
O
Outcome
Changes in ejection fraction (EF) from baseline in percentagesurrogate

ARNI therapy significantly reduces all-cause mortality and cardiovascular death in patients with HFrEF compared to ACEi/ARBs, supporting its use as first-line therapy despite an increased risk of hypotension.

Cite This Study

Haseeb et al. (2023) studied this question.

synapsesocial.com/papers/6a7d0841a88f8d6a789ffacfhttps://doi.org/10.7759/cureus.36392
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of angiotensin-receptor neprilysin inhibitor on reverse cardiac remodeling in patients with heart failure with reduced ejection fraction (hfref)2022 · 2 citations
  2. 2Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure2014 · 6,983 citations
  3. 3Physiology of natriuretic peptides: The volume overload hypothesis revisited2014 · 30 citations
  4. 4Real-world utilisation of angiotensin-neprilysin inhibitors in older adults with heart failure2021 · 2 citations
  5. 5Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction ― Results From the PARALLEL-HF Study ―2021 · 81 citations