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October 3, 2022Heart Failure ReviewsOpen Access

Pooled RR was 0.88 (95% CI: 0.82-0.95) for all-cause mortality, 0.84 (95% CI: 0.77-0.92) for cardiovascular mortality and 0.78 (95% CI: 0.70-0.87) for hospitalization.

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Why the study?

Although guidelines recommend ARNIs as a replacement for ACE inhibitors in heart failure, no reviews had comprehensively covered different aspects of efficacy and safety parameters.

Do angiotensin receptor neprilysin inhibitors improve clinical outcomes and echocardiographic parameters in patients with heart failure?

Population

Heart failure patients across 34 studies

Comparison

ARNIs vs comparator therapies

Design

Systematic review and meta-analysis of randomized controlled trials

Authors

JGJuan GaoCZCong ZhaoWZWenzhong Zhang

Discussion

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Member takes

Overview

Supports ARNI preference over ACEI/ARB in HFrEF; reinforces guidelines with added safety detail on hypotension.

Structured PICO

Do angiotensin receptor neprilysin inhibitors improve clinical outcomes and echocardiographic parameters in patients with heart failure?

P
Population
Heart failure patients (especially those with reduced ejection fraction) from 34 randomized controlled trials
I
Intervention
Angiotensin receptor neprilysin inhibitors (ARNIs)
O
Outcome
All-cause mortalityhard clinical

ARNIs demonstrate a beneficial efficacy profile in heart failure management by significantly reducing mortality and hospitalizations and improving echocardiographic parameters, though they increase the risk of symptomatic hypotension.

Limitations

  • Almost all included studies had a high risk of bias

Cite This Study

Gao et al. (2022) studied this question.

synapsesocial.com/papers/6a86895f7afb35534b942e7ehttps://doi.org/10.1007/s10741-022-10273-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Efficacy and Safety of Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure With Reduced Ejection Fraction: A Meta-Analysis2023 · 6 citations
  2. 2Angiotensin-neprilysin inhibition in acute decompensated heart failure: a systematic review and meta-analysis of randomized controlled trials2025
  3. 3Effect of angiotensin receptor neprilysin inhibitors in patients with STEMI: a systematic review and meta-analysis2025
  4. 4Comparative renal effects of angiotensin receptor neprilysin inhibitors and ACEi/ARB: a systematic review and meta-analysis2025 · 8 citations
  5. 5Angiotensin-neprilysin inhibition in acute decompensated heart failure: a meta-analysis of randomized controlled trials2025