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March 19, 2026Bioresources and BioprocessingOpen Access

The triggered antioxidant response and corresponding metabolomics expression of Caenorhabditis elegans for chronic exposure to moxifloxacin and trace copper

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Authors

LLLili LiuYLY. LiuMTMingqi Tang

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Overview

Investigations reveal oxidative stress impacts antioxidant response in C. elegans, suggesting environmental toxicity implications.

Key Points

  • This research aims to evaluate the toxic effects of moxifloxacin and copper on the health of C. elegans.
  • Conducted physiological, biochemical, and molecular analyses of C. elegans.
  • Assessed gene expressions related to oxidative stress, apoptosis, and antioxidant defense.
  • Evaluated the effect of chronic exposure to moxifloxacin and trace copper over a 10-day period.
  • Prolonged exposure to moxifloxacin inhibited essential stress-response genes in C. elegans.
  • Chronic exposure reduced levels of reactive oxygen species (ROS) while promoting antioxidant gene expression.
  • Exposure to moxifloxacin and copper influenced various metabolic pathways, enhancing antioxidant defenses.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69bb92be496e729e62980579https://doi.org/10.1186/s40643-026-01033-4
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